Research Updates

Cutaneous stem cells and cancer

15 October 2008

Stephen Lyle, M.D., Ph.D.
In the last several years there has been a great deal of interest in the relationship between stem cells and cancer. In this article, Dr. Stephen Lyle considers several aspects of stem cell biology that apply to cancer, while focusing on the skin. Dr. Lyle believes that the application of advances in stem cell biology to cancer research can lead to a better understanding of what drives carcinogenesis, tumor progression, recurrence and metastasis, and that the localization of keratinocyte, melanocyte and neural crest-derived stem cells in the bulge region of the skin provides an excellent model system to study the relationship of stem cells and cancer.

IL-12 and IL-23 and Psoriasis

11 July 2008

Steven R. Feldman, MD, PhD
Inhibitors of IL-12 and IL-23 appear to be very potent treatments for psoriasis. Dr. Steven Feldman believes that if they prove to be very safe, another quantum leap in treatment for patients with severe psoriasis may be achieved.

Comorbidities in Psoriasis: Part Two

06 November 2007

Dr. Joel Gelfand
Psoriasis is a common chronic inflammatory disease of the skin that has been associated with a variety of comorbidities.