Historically, dermatologists dreamt of observing the fine
structure of living skin, because conventional methods were based
on histological analysis that allowed us to evaluate only a
two-dimensional slice of a certain time point without time or space
components. Furthermore, the morphology of skin components may be
distorted as a result of the multiple fixation and staining steps.
Now, dreams have come true using a novel imaging tool, two-photon
microscopy (TPM), with which real-time imaging studies of both
anatomic structures and cutaneous reactions are possible. In this
article, the fine structures of living skin components, as well as
some inflammatory reactions, will be shown as movies.