Answer: Oral fibroma
Criteria for diagnosis
histopathologically: A papule made up of fibrous
tissue with an increased number of fibrocytes in foci is consonant
with an oral fibroma.
Differential diagnosis histopathologically:
There is none.
Criteria for diagnosis clinically: A
dome-shaped, well-demarcated papule with a smooth surface on the
lateral aspect of the tongue is characteristic of oral fibroma.
Differential diagnosis clinically: There is
Clinicopathologic correlation: The papule
results from the proliferation of fibrous tissue. The surface of
the papule is smooth because the mucous membrane is not
Options for therapy predicated on knowledge of
histopathologic findings: The oral fibroma developed
in response to repeated bite trauma. Once it has developed,
surgical removal is the therapy of choice.
1) Oral fibroma is common and usually develops on sites of bite
trauma within the oral cavity (tongue, buccal mucosa). It is not a
neoplasm, but a reactive proliferation of fibrous tissue.
2) Giant-cell fibroma has been described as a variant of oral
fibroma in which the number of giant cells dominates over single
stellate fibroblasts. Other variants include fibromas containing
significant amounts of fat (fibrolipomas) and fibromas with myxoid
changes. Chronic mechanical trauma is the common causative factor.
Some authors regard all lesions as a single reactive fibrotic
process with different morphologic patterns, each with its own
histopathologic characteristic but overlapping in the clinical
presentation. In sum, all types of fibrous lesions of the oral
cavity are merely different histologic responses to a common