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CONCLUSIONS: The clinical history and the results of the allergologic investigations, plus an on-the-spot inspection, permitted us to ascertain that this subject had developed occupational asthma due to Pleurotus ostreatus spores. We advised her to stop handling and selling mushrooms, and she has no longer suffered asthmatic symptoms, over seven years of follow-up, and regularly continued to work without needing to take anti-asthma drugs. PMID: 27015024 [PubMed - as supplied by publisher] (Source: Medicina del Lavoro)

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Lipoid proteinosis.

Sun, 27 Mar 2016

Authors: Kartal D, Çınar SL, Kartal L, Saka ÖŞ, Borlu M Abstract Lipoid proteinosis (LP) is an uncommon, autosomal, recessively inherited disorder. It is typically characterized by hoarseness from early infancy, together with various cutaneous manifestations such as waxy papules, acneiform scarring, and eyelid beading. A 42-year-old woman was admitted to our dermatology outpatient clinic complaining of rigidity of the oral mucosa and limitation in tongue movement. She also had a burning sensation and decreased taste perception in the mouth while eating, as well as hoarseness of voice. She was diagnosed with lipoid proteinosis. The typical cutaneous manifestations of LP include waxy yellow papules with generalized skin thickening on the face, extremities, and trunk. Here we repo...

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We report a 19-year-old male patient with a 2-week history of pruritic, scaling dermatosis of the hands, feet, elbows, and knees. He had no family history of skin disease. On physical examination, we observed circumscribed, reddish-orange, scaling plaques affecting the elbows and knees and a waxy palmoplantar keratoderma. The skin biopsy showed acanthosis, alternating orthokeratosis, parakeratosis, and follicular plugging suggestive of pityriasis rubra pilaris. The patient started treatment with oral acitretin, 25 mg every other day. The treatment was tolerated well, and after 6 months the lesions had resolved completely. Pityriasis rubra pilaris is a chronic papulosquamous disorder of unknown pathogenesis, characterized by reddish-orange scaly plaques, palmoplantar keratoderma, and kerato...

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We present a patient with HPV 70/85-positive widespread cutaneous warts characterized by clinical and histological features atypical for classic generalized verrucosis or epidermodysplasia verruciformis. The cutaneous HPV infection is characterized by verrucous papules or plaques variable in size, number, and distribution depending on the genotype of HPV involved and the immune status of the patient. Human papillomaviruses comprise five genera (alpha, beta, gamma, mu, and nu papillomavirus) with different life-cycle characteristics, epithelial tropisms, and disease associations. Epidermodysplasia verruciformis (EV) is a rare, lifelong, autosomal recessive skin disease characterized by persistent cutaneous human papillomavirus infection not necessarily associated with immune system defects...

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CONCLUSION: In some vitiligo patients the residual melanocytes are preserved in depigmented skin. Melan-A marker is useful for identi cation of melanocytes in vitiligo patients' skin. PMID: 27014772 [PubMed - in process] (Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica)

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CONCLUSION: ACEI was shown to be the most frequent removable cause of isolated AE. About two-thirds of AE cases taking ACEI were resolved after removal of the drug. PMID: 27014771 [PubMed - in process] (Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica)

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Authors: Lopes C, Rocha L, Sokhatska O, Soares J, Tavaria F, Correia O, Pintado M, Fernandes S, Delgado L, Moreira A PMID: 27012026 [PubMed - in process] (Source: Journal of Investigational Allergology and Clinical Immunology)

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ConclusionsHair dye products with the less sensitizing ME‐PPD were tolerated by 29 of 43 (67%) PPD/PTD‐allergic individuals throughout continued hair dyeing with an average of nine treatments per year. Five individuals reacted upon pretesting, while only mild‐to‐moderate/marked skin reactions occurred upon hair dyeing in nine individuals who were not identified by the pretest. To our knowledge this is the first study among PPD/PTD‐allergic individuals indicating that a negative 45‐min pretest with a hair dye product helps to avoid severe allergic reactions. (Source: British Journal of Dermatology)

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ConclusionsThis study demonstrates a high prevalence of several psychiatric disorders (anxiety, depression, suicide risk, alcohol dependence) in patients with SRL. (Source: British Journal of Dermatology)

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Conclusion Referring physicians of children with burns were overall well informed: they cool the wound after burns and cover it before transport to prevent hypothermia and reduce the pain. Additional studies should be conducted to clarify the duration and temperature for cooling to be effective. Furthermore, there is room and a need for improvement regarding early pain management. (Source: Burns)

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Conclusion Evidence about decreased incidence of VAP in burn patients with inhalation injuries who are on HFPV compared to those on VCV is inconclusive. Although enhanced airway clearance by HFPV was thought to play a role in decreasing VAP in this population, high tidal volume in the VCV arms could be a confounding factor that should be eliminated in future studies before a firm conclusion can be reached. More RCTs comparing HFPV to low tidal volume VCV are needed. (Source: Burns)

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Authors: Quirk SK, Rainwater E, Shure AK, Agrawal DK Abstract Vitamin D influences allergen-induced pathways in the innate and adaptive immune system, and its potential immunomodulatory role in allergic skin disorders has been explored. This comprehensive review article provides an overview of the role of vitamin D in three common dermatologic conditions: atopic dermatitis (AD), chronic urticaria, and allergic contact dermatitis (ACD). Whereas the literature regarding vitamin D and AD has resulted in mixed findings, several studies have described an inverse relationship between vitamin D levels and AD severity, and improvement in AD with vitamin D supplementation. Similarly, several studies report an inverse relationship between vitamin D levels and severity of chronic urticaria. A...

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CONCLUSION: Quercetin has a skin protective effect against damage caused by a variety of insults, including UV radiation, histamine, or contact with toxic chemical compounds. Indeed, quercetin is able to reduce redness, itching, and inflammation of damaged skin; it may also help restore skin barrier function, increasing hydration, and reducing water loss. PMID: 27013898 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)

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CONCLUSIONS: The results were consistent with the scientific literature in the field. The experience seems to confirm the opportunity of screening programs on arthropathy in cutaneous psoriasis patients. About a quarter of psoriasis patients had relevant arthropathic features, and more than half of these required challenging therapies like biologics. PMID: 27013149 [PubMed - as supplied by publisher] (Source: Giornale Italiano di Dermatologia e Venereologia)

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Authors: Lembo S, DI Caprio R, Balato A, Bigioni AR, Caiazzo G, Schiattarella M, Monfrecola G PMID: 27013148 [PubMed - as supplied by publisher] (Source: Giornale Italiano di Dermatologia e Venereologia)

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CONCLUSIONS: In our octogenarians, death for CM was not related to the old age but to the delayed diagnosis of cancer. Our results suggest that continuing educational programs for early diagnosis of CM should specifically include this segment of population. PMID: 27013147 [PubMed - as supplied by publisher] (Source: Giornale Italiano di Dermatologia e Venereologia)

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Atopic dermatitis (AD) is a chronic, or chronically relapsing, inflammatory skin disease and it is the most common chronic disease of childhood.1 Inflammatory processes are known to play an important role in the development of psychiatric diseases.2 Attention deficit/hyperactivity disorder (ADHD) is one of the most common childhood psychiatric disorders.3 However, only 1 questionnaire-based follow-up study exists on the association between AD and ADHD and it does not report results related to sex. (Source: Journal of Allergy and Clinical Immunology)

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Keloid disease (KD) is a recurrent fibroproliferative, cutaneous tumour of unknown pathogenesis whose clinical management remains unsatisfactory. To obtain new insights into hitherto underappreciated aspects of keloid pathobiology, we took a laser capture microdissection-based whole genome microarray analysis approach to identify distinct KD-associated gene expression patterns within defined keloid regions. Identification of the aldo-keto reductase enzyme AKR1B10 as highly upregulated in keloid epidermis suggested an imbalance of retinoic acid (RA) metabolism is likely associated with KD. (Source: Journal of Investigative Dermatology)

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Abstract Excessive exposure to the sun's radiation is the major exogenous mediator of skin damage, which accelerates skin ageing and increases the risk of developing skin cancer. Compounds with photoprotectant activity are extremely useful for decreasing the effect of ultraviolet (UV) radiation on the skin; however, numerous sun filters, especially organic sunscreens, are allergenic. Therefore, the development of formulations containing plant extracts, which may be potentially safer, is extensively being explored. Plant‐based cosmetics are commonly used to avoid skin ageing because they contain antioxidant agents that minimize free radical activity, and numerous studies have investigated the skin‐protectant effects of related plant species. In addition to their antioxidant properties, ...

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